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wholesale jerseys Top of pageResultsGene Cloning and Transgenic StrainsWe cloned the normal and mutant TTR genes from the genomic DNA of an individual with a clinically aggressive form of the autosomal dominant disorder FAP (Jacobson et al, 1992). Each allele was contained on an identical 19.2 kb fragment that differed only by the diagnostic base substitution (TC) in exon 3, accounting for the LeuPro amino acid substitution at position 55 (TTR Leu55Pro). The structure of the cloned genomic fragment used to produce the transgenics is shown in Figure 1. wholesale jerseys
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